Nuclear export

Across TCGA cell cohorts, RNA activity of the Nuclear export pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HGD, NONO, and USP39, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear export activity versus HGD in PANCREAS (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HGD →	-1.089	-0.194	.005	<.001	3	6
OESOPHAGUS	NONO →	+0.734	+0.168	<.001	.003	2	7
OVARY	USP39 →	+0.546	+0.176	.004	.001	3	6
LUNG_NSCLC_LUAD	HCFC1 →	+0.356	+0.167	.005	.002	2	7
LUNG_NSCLC_LUAD	MCM2 →	+0.540	+0.148	.004	.003	3	6
BONE	PUS1 →	+0.892	+0.265	.009	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051168 vs HGD — PANCREAS

Explore this scatter interactively →