Xylulose 5-phosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Xylulose 5-phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTTG1, CDCA5, and FEN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xylulose 5-phosphate metabolic process activity versus PTTG1 in LUAD (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PTTG1 →	-0.846	-0.098	<.001	.002	3	7
LUAD	CDCA5 →	-0.703	-0.090	.001	.003	3	6
BRCA	FEN1 →	-0.607	-0.133	.001	.001	3	6
PDAC	MIR4499 →	+0.596	+0.067	.003	.001	3	6
LSCC	ASF1B →	-0.670	-0.097	<.001	<.001	3	5
BRCA	ASPA →	+0.517	+0.090	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051167 vs PTTG1 — LUAD

Explore this scatter interactively →