Glucose 6-phosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Glucose 6-phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA8, CBLB, and KHDC4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUBA8 grouped by Glucose 6-phosphate metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TUBA8 →	-0.508	-1.181	.004	<.001	3	4
OVARY	CBLB →	-1.229	-1.205	<.001	<.001	3	4
OVARY	KHDC4 →	-0.702	-0.834	.005	.002	3	4
PANCREAS	TIMM44 →	-1.138	-0.990	.002	.002	2	5
BLOOD_Lymphoma	ZNF284 →	-0.983	-1.934	.001	<.001	3	4
SOFT_TISSUE	CNKSR3 →	-1.715	-1.262	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUBA8 by Glucose 6-phosphate metabolic process activity — STOMACH

Explore this box plot interactively →