Regulation of NK T cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of NK T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLAMF6, IGKV2-30, and LCP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of NK T cell differentiation activity versus SLAMF6 in UCEC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLAMF6 →	+0.664	+0.693	.002	<.001	3	4
UCEC	IGKV2-30 →	+1.130	+0.645	.003	.001	3	4
LSCC	LCP1 →	+0.845	+0.849	<.001	.002	2	5
GBM	IGHV3-74 →	+0.740	+0.090	.005	.001	3	4
GBM	PCGF2 →	-0.455	-0.111	<.001	.003	3	4
LSCC	DOCK8 →	+0.876	+0.736	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051136 vs SLAMF6 — UCEC

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