Chaperone-mediated protein complex assembly

Across TCGA patient cohorts, RNA activity of the Chaperone-mediated protein complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHJ1, KCNMB1, and CHCHD4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chaperone-mediated protein complex assembly activity versus PLEKHJ1 in COAD (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLEKHJ1 →	+0.296	+0.090	.002	.001	3	5
BRCA	KCNMB1 →	-0.437	-0.108	.002	.001	3	4
HNSC	CHCHD4 →	+0.468	+0.075	.004	.005	3	4
HNSC	MAMDC2-AS1 →	-0.617	-0.089	.002	.004	2	5
BRCA	CEBPB →	-0.668	-0.102	.005	.001	3	4
GBM	CRP →	-0.061	-0.087	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051131 vs PLEKHJ1 — COAD

Explore this scatter interactively →