Chaperone-mediated protein complex assembly

Across TCGA cell cohorts, RNA activity of the Chaperone-mediated protein complex assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LONP1, HSPD1, and CCT2, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LONP1 grouped by Chaperone-mediated protein complex assembly-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	LONP1 →	-0.508	-0.403	.001	.003	3	13
LUNG_SCLC	HSPD1 →	-0.641	-0.293	<.001	.004	3	12
SOFT_TISSUE	CCT2 →	-0.379	-0.322	.005	.002	3	10
URINARY_TRACT	KMT5C →	-0.319	-0.207	.002	.002	3	4
LARGE_INTESTINE	D2HGDH →	-0.160	-0.220	.005	.007	3	4
UPPER_AERODIGESTIVE_TRACT	PSMG1 →	-0.521	-0.347	.008	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LONP1 by Chaperone-mediated protein complex assembly activity — LIVER

Explore this box plot interactively →