Chaperone-mediated protein complex assembly

Across TCGA cell cohorts, RNA activity of the Chaperone-mediated protein complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VSIR, ICAM1, and GNAI3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VSIR grouped by Chaperone-mediated protein complex assembly-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	VSIR →	+2.411	+0.205	<.001	<.001	3	5
OESOPHAGUS	ICAM1 →	+3.069	+0.179	.005	.004	2	6
STOMACH	GNAI3 →	+0.589	+0.302	<.001	<.001	3	5
LUNG_SCLC	ITGA5 →	+3.232	+0.290	<.001	.001	3	5
SOFT_TISSUE	CENPN →	+0.690	+0.347	.001	.004	3	5
STOMACH	MYH9 →	+1.368	+0.303	.003	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VSIR by Chaperone-mediated protein complex assembly activity — OESOPHAGUS

Explore this box plot interactively →