Chaperone-mediated protein complex assembly

Across TCGA cell cohorts, RNA activity of the Chaperone-mediated protein complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MICOS13, SNRNP40, and CLPP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chaperone-mediated protein complex assembly activity versus MICOS13 in BREAST (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MICOS13 →	+0.898	+0.270	<.001	<.001	3	7
STOMACH	SNRNP40 →	+0.689	+0.151	.002	.006	3	6
OVARY	CLPP →	+1.051	+0.267	.002	.001	3	6
BONE	LONP1 →	+1.307	+0.227	.001	<.001	2	7
OVARY	AFAP1L2 →	-3.224	-0.252	<.001	.004	3	6
OVARY	DAPP1 →	-2.502	-0.259	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051131 vs MICOS13 — BREAST

Explore this scatter interactively →