Negative regulation of actin nucleation

Across TCGA patient cohorts, RNA activity of the Negative regulation of actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL18BP, CIITA, and PRAM1, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of actin nucleation activity versus IL18BP in UVM (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	IL18BP →	+1.767	+0.068	<.001	<.001	3	30
SCLC	CIITA →	+1.891	+0.186	<.001	<.001	3	30
KIRP	PRAM1 →	+0.921	+0.073	<.001	<.001	3	29
CHOL	ITGAX →	+1.943	+0.144	<.001	<.001	3	29
LGG	TREML1 →	+0.656	+0.048	<.001	<.001	3	29
CHOL	CSF2RB →	+1.700	+0.099	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051126 vs IL18BP — UVM

Explore this scatter interactively →