Negative regulation of actin nucleation

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of actin nucleation pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Negative regulation of actin nucleation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

UVM, HNSC, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.369	0.829	<.001	75	view →
HNSC	DFS	Median	III,IV	0.743	0.583	<.001	64	view →
SKCM	OS	Tertile	All	0.562	0.279	<.001	50	view →
SCLC	OS	Median	All	0.726	0.420	<.001	42	view →
MESO	OS	Quartile	IV	0.511	0.928	.008	39	view →
LGG	DFS	Median	All	0.665	0.794	<.001	36	view →
UCEC	DFS	Quartile	II,III,IV	0.786	0.473	.011	26	view →
STAD	DFS	Median	All	0.712	0.321	<.001	18	view →
ESCA	DFS	Tertile	III,IV	0.472	0.255	.023	16	view →
LUSC	DFS	Median	II,III,IV	0.295	0.484	.014	16	view →
READ	DFS	Tertile	II,III,IV	0.920	0.719	.025	16	view →
PRAD	DFS	Quartile	All	0.806	0.925	.002	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0051126–UVM (OS)

Open the UVM breakdown →