Negative regulation of actin nucleation

Across TCGA cell cohorts, RNA activity of the Negative regulation of actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CADPS2, PCNX1, and NOC3L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CADPS2 grouped by Negative regulation of actin nucleation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CADPS2 →	+1.695	+0.671	.003	.002	3	4
PANCREAS	PCNX1 →	-0.652	-1.640	.004	<.001	3	4
BREAST	NOC3L →	-0.510	-0.424	.002	.005	3	3
LIVER	REEP6 →	+3.163	+1.431	<.001	.006	3	3
BREAST	PRODH →	+2.436	+0.521	<.001	<.001	3	3
BREAST	TELO2 →	+0.714	+0.398	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CADPS2 by Negative regulation of actin nucleation activity — BREAST

Explore this box plot interactively →