RNA polymerase II preinitiation complex assembly

Across TCGA cell cohorts, RNA activity of the RNA polymerase II preinitiation complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VGLL1, C15orf61, and SNRNP48, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA polymerase II preinitiation complex assembly activity versus VGLL1 in STOMACH (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	VGLL1 →	-3.027	-0.622	.005	<.001	3	6
LUNG_NSCLC_LUAD	C15orf61 →	+0.382	+0.368	<.001	<.001	3	5
LARGE_INTESTINE	SNRNP48 →	+0.564	+0.418	.001	.001	3	4
BLOOD_Lymphoma	DDX58 →	-1.283	-0.463	<.001	.005	3	4
STOMACH	OAZ1 →	+0.806	+1.017	.007	<.001	3	4
STOMACH	NDUFS7 →	+1.115	+0.614	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051123 vs VGLL1 — STOMACH

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