Regulation of DNA binding

Across TCGA patient cohorts, RNA activity of the Regulation of DNA binding pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ABT1, CAD, and NOL10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA binding activity versus ABT1 in PDAC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ABT1 →	+0.352	+0.025	.002	<.001	3	7
LUAD	CAD →	+0.244	+0.033	<.001	<.001	3	6
COAD	NOL10 →	+0.160	+0.017	.001	.001	3	6
LUAD	OBI1_S210 →	+0.841	+0.036	<.001	.001	3	6
PDAC	TOP2A_S1377 →	+1.540	+0.032	<.001	.001	3	6
LUAD	MSH6 →	+0.463	+0.041	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051101 vs ABT1 — PDAC

Explore this scatter interactively →