Negative regulation of binding

Across TCGA cell cohorts, RNA activity of the Negative regulation of binding pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR77, MTMR4, and BRIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR77 grouped by Negative regulation of binding-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	WDR77 →	+0.906	+0.258	.001	<.001	3	5
BLOOD_Leukemia	MTMR4 →	+1.196	+0.386	<.001	.005	3	4
LUNG_SCLC	BRIP1 →	+1.012	+0.282	.007	.002	2	5
LUNG_SCLC	BAZ1A →	+0.915	+0.284	<.001	.001	3	4
LARGE_INTESTINE	ACADM →	+0.751	+0.171	.003	<.001	3	3
LARGE_INTESTINE	IQGAP2 →	-2.192	-0.121	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR77 by Negative regulation of binding activity — BLOOD_Leukemia

Explore this box plot interactively →