Regulation of binding

Across TCGA cell cohorts, RNA activity of the Regulation of binding pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB9, HLA-B, and TAP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of binding activity versus PSMB9 in BREAST (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PSMB9 →	-2.919	-0.122	<.001	.003	3	8
PANCREAS	HLA-B →	-3.153	-0.147	.001	.007	3	7
BONE	TAP1 →	-2.913	-0.291	.007	.002	3	6
BREAST	TAPBP →	-1.231	-0.132	<.001	<.001	3	6
LUNG_SCLC	GNG12 →	-1.810	-0.181	.003	.002	3	5
PANCREAS	HLA-F →	-2.567	-0.182	.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051098 vs PSMB9 — BREAST

Explore this scatter interactively →