Negative regulation of small GTPase mediated signal transduction

pathway activity — cross-omics
GO:0051058Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Negative regulation of small GTPase mediated signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S120, DCN, and GPX3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of small GTPase mediated signal transduction activity versus TNS2_S120 in LSCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCTNS2_S120 →+0.502+0.039<.001<.00139
BRCADCN →+1.114+0.038<.001<.00139
BRCAGPX3 →+0.765+0.033<.001<.00139
OVLUM →+1.086+0.067<.001<.00139
HNSCHAAO →+0.546+0.053<.001<.00139
UCECKANK2 →+0.706+0.042<.001.00439
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051058 vs TNS2_S120 — LSCC

Per-sample scatter of Negative regulation of small GTPase mediated signal transduction activity vs TNS2_S120 in LSCC.

Explore this scatter interactively →

Exploration