Negative regulation of lipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of lipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C3orf52, EHHADH, and TPP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipid biosynthetic process activity versus C3orf52 in LUNG_NSCLC_LUSC (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C3orf52 →	-1.672	-0.252	.006	.008	3	5
BONE	EHHADH →	+0.768	+0.348	.001	.004	3	5
BLOOD_Leukemia	TPP1 →	+0.705	+0.307	.002	.002	3	5
SKIN	BBS4 →	+0.617	+0.219	.001	<.001	3	4
BLOOD_Myeloma	WASHC5 →	+1.253	+0.340	.005	.005	3	4
BLOOD_Leukemia	DUSP3 →	+1.558	+0.284	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051055 vs C3orf52 — LUNG_NSCLC_LUSC

Explore this scatter interactively →