Negative regulation of DNA metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of DNA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMELESS_S1173, LIG1, and MCM2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA metabolic process activity versus TIMELESS_S1173 in LSCC (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TIMELESS_S1173 →	+0.680	+0.032	<.001	<.001	3	9
LUAD	LIG1 →	+0.524	+0.048	<.001	<.001	3	9
LUAD	MCM2 →	+0.844	+0.051	<.001	<.001	3	9
LUAD	MCM7 →	+0.855	+0.052	<.001	<.001	3	9
LSCC	MSH6 →	+0.501	+0.032	<.001	<.001	3	9
LSCC	CDK2 →	+0.290	+0.029	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051053 vs TIMELESS_S1173 — LSCC

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