Negative regulation of membrane protein ectodomain proteolysis

Across TCGA patient cohorts, RNA activity of the Negative regulation of membrane protein ectodomain proteolysis pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THEMIS2_T593, THEMIS2, and BRMS1L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of membrane protein ectodomain proteolysis activity versus THEMIS2_T593 in HNSC (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	THEMIS2_T593 →	-0.525	-0.081	<.001	<.001	3	7
GBM	THEMIS2 →	-0.415	-0.064	<.001	<.001	3	6
LUAD	BRMS1L →	+0.201	+0.064	.005	.002	3	6
HNSC	ISG20 →	-0.460	-0.070	.006	.002	3	6
COAD	ARHGAP45_S619 →	-0.670	-0.042	<.001	<.001	3	6
LUAD	GRB2 →	-0.287	-0.067	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051045 vs THEMIS2_T593 — HNSC

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