Negative regulation of membrane protein ectodomain proteolysis

Across TCGA cell cohorts, RNA activity of the Negative regulation of membrane protein ectodomain proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLIP1, SYCE1L, and MID2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLIP1 grouped by Negative regulation of membrane protein ectodomain proteolysis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CLIP1 →	-0.917	-0.510	.002	.009	2	5
LUNG_NSCLC_LUAD	SYCE1L →	-0.853	-0.688	.008	.007	3	4
OVARY	MID2 →	-1.299	-1.245	<.001	<.001	3	4
PANCREAS	VAPA →	-0.612	-0.690	<.001	.003	3	4
BREAST	OSR2 →	-1.221	-0.805	.002	.007	3	4
LUNG_SCLC	SLC9A6 →	+0.689	+1.578	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLIP1 by Negative regulation of membrane protein ectodomain proteolysis activity — SOFT_TISSUE

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