Regulation of endosome size

Across TCGA patient cohorts, RNA activity of the Regulation of endosome size pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRM1, HAAO, and NAA50, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endosome size activity versus RRM1 in UCEC (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RRM1 →	-0.457	-0.056	.004	.007	3	6
GBM	HAAO →	+0.404	+0.043	<.001	<.001	3	6
GBM	NAA50 →	-0.207	-0.049	.001	<.001	3	6
BRCA	ATL1_S10 →	+0.619	+0.029	<.001	<.001	3	5
GBM	PRMT1 →	-0.328	-0.051	<.001	<.001	3	5
CCRCC	SH3KBP1_S230 →	+0.673	+0.026	<.001	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051036 vs RRM1 — UCEC

Explore this scatter interactively →