snRNA transport

Across TCGA patient cohorts, RNA activity of the snRNA transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIN3A, SNUPN, and YWHAE, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA transport activity versus SIN3A in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SIN3A →	+0.302	+0.058	<.001	<.001	3	8
BRCA	SNUPN →	+0.284	+0.033	<.001	<.001	3	6
LSCC	YWHAE →	+0.235	+0.055	<.001	<.001	3	6
BRCA	TP53BP1 →	+0.274	+0.035	.003	<.001	3	5
COAD	HARS2 →	-0.319	-0.031	.001	<.001	3	5
HNSC	MORF4L1 →	+0.252	+0.054	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051030 vs SIN3A — LSCC

Explore this scatter interactively →