snRNA transport

Across TCGA patient cohorts, RNA activity of the snRNA transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEACAM3, OSER1-DT, and CSF3R, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA transport activity versus CEACAM3 in HNSC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CEACAM3 →	-0.452	-0.172	.001	.003	3	4
LSCC	OSER1-DT →	-0.330	-0.128	.006	.003	3	3
UCEC	CSF3R →	-0.866	-0.176	.006	.005	3	3
CCRCC	HCAR3 →	-0.685	-0.123	.008	.003	3	3
CCRCC	EMC4 →	+0.193	+0.121	<.001	.004	3	3
CCRCC	HNRNPK →	+0.192	+0.130	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051030 vs CEACAM3 — HNSC

Explore this scatter interactively →