rRNA transport

Across TCGA cell cohorts, RNA activity of the rRNA transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TST, LNPK, and TTC38, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA transport activity versus TST in LIVER (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TST →	+2.521	+0.453	.002	.005	3	9
STOMACH	LNPK →	-1.087	-0.306	<.001	<.001	3	6
OESOPHAGUS	TTC38 →	+0.648	+0.256	.008	<.001	3	5
URINARY_TRACT	FKBP15 →	-0.665	-0.346	.008	.009	2	6
OESOPHAGUS	DAB2IP →	+1.367	+0.317	.007	<.001	3	5
OESOPHAGUS	SPNS2 →	+2.124	+0.277	.006	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051029 vs TST — LIVER

Explore this scatter interactively →