mRNA transport

Across TCGA patient cohorts, RNA activity of the mRNA transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, ADNP, and SMC1A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA transport activity versus TOP2A in HNSC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TOP2A →	+1.018	+0.095	<.001	<.001	3	7
GBM	ADNP →	+0.378	+0.043	.001	.003	3	7
HNSC	SMC1A →	+0.341	+0.103	<.001	<.001	3	7
LSCC	SMC3 →	+0.311	+0.051	<.001	.001	3	7
LSCC	TRMT6 →	+0.383	+0.048	.001	.002	3	7
LSCC	DEK →	+0.408	+0.056	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051028 vs TOP2A — HNSC

Explore this scatter interactively →