mRNA transport

Across TCGA cell cohorts, RNA activity of the mRNA transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDELR3, RPS27L, and USP49, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA transport activity versus KDELR3 in CNS (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KDELR3 →	-1.324	-0.145	<.001	.009	3	7
SOFT_TISSUE	RPS27L →	-1.830	-0.257	.009	<.001	3	7
BLOOD_Lymphoma	USP49 →	+1.235	+0.153	.008	.005	3	7
BREAST	PRR3 →	+0.679	+0.261	.002	<.001	3	7
BLOOD_Lymphoma	CPEB4 →	-2.029	-0.142	.002	.008	3	7
LARGE_INTESTINE	SCD5 →	+1.888	+0.154	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051028 vs KDELR3 — CNS

Explore this scatter interactively →