Chiasma assembly

Across TCGA patient cohorts, RNA activity of the Chiasma assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VPS13C, RRP9, and RFC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chiasma assembly activity versus VPS13C in BRCA (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VPS13C →	-0.355	-0.072	<.001	<.001	3	8
UCEC	RRP9 →	+0.403	+0.106	.002	.009	3	8
BRCA	RFC1 →	+0.376	+0.064	<.001	.002	3	7
LSCC	RFC2 →	+0.430	+0.155	<.001	<.001	3	7
BRCA	RPRD2 →	+0.347	+0.094	<.001	<.001	3	7
GBM	SF3B3 →	+0.220	+0.065	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051026 vs VPS13C — BRCA

Explore this scatter interactively →