Chiasma assembly

Across TCGA cell cohorts, RNA activity of the Chiasma assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPCS, TMC4, and BLVRB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPCS grouped by Chiasma assembly-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PPCS →	-0.631	-1.582	.002	<.001	3	5
LARGE_INTESTINE	TMC4 →	-1.774	-1.072	.002	.003	3	5
STOMACH	BLVRB →	-1.322	-1.686	<.001	<.001	3	5
SOFT_TISSUE	CCDC159 →	-2.028	-1.426	<.001	<.001	3	4
SOFT_TISSUE	SLC22A5 →	-1.591	-1.789	.007	<.001	3	4
BLOOD_Myeloma	CEP170B →	-1.960	-0.593	.006	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPCS by Chiasma assembly activity — STOMACH

Explore this box plot interactively →