Actin filament severing

Across TCGA patient cohorts, RNA activity of the Actin filament severing pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLI1, BST1, and PLXNC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin filament severing activity versus FLI1 in OV (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FLI1 →	+0.823	+0.290	<.001	<.001	3	8
GBM	BST1 →	+0.559	+0.179	.001	<.001	3	8
HNSC	PLXNC1 →	+0.655	+0.179	.001	<.001	3	8
OV	CMAHP →	+0.993	+0.278	.001	<.001	3	8
OV	CCN4 →	+1.524	+0.254	<.001	<.001	3	8
OV	CXCL12 →	+1.853	+0.280	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051014 vs FLI1 — OV

Explore this scatter interactively →