Actin filament severing

Across TCGA cell cohorts, RNA activity of the Actin filament severing pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNRC6B, ARHGAP12, and PAM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNRC6B grouped by Actin filament severing-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TNRC6B →	+0.690	+0.619	.003	.009	3	4
OESOPHAGUS	ARHGAP12 →	-1.121	-1.556	.001	.006	3	3
OVARY	PAM →	-2.030	-1.010	<.001	.007	3	3
LUNG_SCLC	RNF113A →	-1.092	-1.322	<.001	<.001	3	3
CNS	DHX58 →	-1.146	-0.700	<.001	.004	3	3
CNS	GINS2 →	+0.732	+0.821	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNRC6B by Actin filament severing activity — KIDNEY

Explore this box plot interactively →