Actin filament severing

Across TCGA cell cohorts, RNA activity of the Actin filament severing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED4, UBL7, and TRAPPC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin filament severing activity versus MED4 in BLOOD_Myeloma (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MED4 →	+0.628	+0.291	.009	<.001	3	5
LIVER	UBL7 →	+0.551	+0.495	.008	<.001	3	5
KIDNEY	TRAPPC1 →	+0.840	+0.508	.001	.002	3	5
BLOOD_Lymphoma	NFKB1 →	+0.935	+0.221	.002	<.001	2	5
BLOOD_Lymphoma	AMY2A →	+0.022	+0.200	.009	.005	3	4
LIVER	PREP →	+0.708	+0.488	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051014 vs MED4 — BLOOD_Myeloma

Explore this scatter interactively →