Positive regulation of nitric-oxide synthase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of nitric-oxide synthase activity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SON_T959, CPM, and AATF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nitric-oxide synthase activity activity versus SON_T959 in LSCC (Pearson r = -0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SON_T959 →	-0.467	-0.056	<.001	<.001	3	4
LUAD	CPM →	+0.616	+0.048	<.001	<.001	3	4
BRCA	AATF →	+0.372	+0.042	.002	.005	3	3
COAD	SQLE →	+0.446	+0.034	.006	.004	3	3
COAD	TNIK_S678 →	-0.364	-0.032	<.001	.007	3	3
LUAD	TNIK_S769 →	-0.485	-0.049	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051000 vs SON_T959 — LSCC

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