Positive regulation of nitric-oxide synthase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of nitric-oxide synthase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A1, TERF2, and ITGB2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, S100A1 grouped by Positive regulation of nitric-oxide synthase activity-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	S100A1 →	-0.655	-2.100	.001	<.001	3	8
CNS	TERF2 →	-0.171	-0.678	.004	.004	3	4
LARGE_INTESTINE	ITGB2 →	+0.176	+0.810	.006	.005	3	4
LARGE_INTESTINE	IL17RC →	-0.160	-1.155	.006	.001	3	4
OVARY	HMGB4 →	-0.182	-0.760	.003	<.001	3	4
LUNG_NSCLC_LUSC	UGT3A1 →	+0.144	+0.334	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

S100A1 by Positive regulation of nitric-oxide synthase activity activity — BLOOD_Myeloma

Explore this box plot interactively →