Positive regulation of nitric-oxide synthase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of nitric-oxide synthase activity pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SORD, POF1B, and ROBO3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SORD grouped by Positive regulation of nitric-oxide synthase activity-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SORD →	+0.693	+1.155	.003	.004	3	5
BLOOD_Myeloma	POF1B →	+0.620	+1.660	.008	<.001	2	5
BREAST	ROBO3 →	-1.717	-0.838	.001	.001	3	4
BREAST	LRRC8D →	-0.948	-0.918	<.001	<.001	3	4
BLOOD_Leukemia	ZC2HC1A →	-1.017	-1.512	<.001	.001	3	4
BREAST	TSPAN13 →	+2.414	+0.984	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SORD by Positive regulation of nitric-oxide synthase activity activity — STOMACH

Explore this box plot interactively →