Positive regulation of nitric-oxide synthase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of nitric-oxide synthase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAOK1, HMG20B, and LMAN2L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAOK1 grouped by Positive regulation of nitric-oxide synthase activity-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TAOK1 →	+0.298	+1.925	.003	<.001	3	5
LUNG_NSCLC_LUAD	HMG20B →	+0.130	+0.873	.006	.004	3	5
BREAST	LMAN2L →	+0.237	+1.011	<.001	.002	3	5
LUNG_SCLC	KDM1A →	+0.350	+1.008	<.001	.006	3	4
LIVER	RAG2 →	-0.396	-1.451	<.001	<.001	3	4
BREAST	PSMA3 →	-0.560	-1.220	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAOK1 by Positive regulation of nitric-oxide synthase activity activity — LIVER

Explore this box plot interactively →