Regulation of nitric-oxide synthase activity

Across TCGA patient cohorts, RNA activity of the Regulation of nitric-oxide synthase activity pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMARCA4, TLR2, and HK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nitric-oxide synthase activity activity versus SMARCA4 in OV (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMARCA4 →	-0.310	-0.053	.004	<.001	3	5
LSCC	TLR2 →	+0.410	+0.050	<.001	<.001	3	5
GBM	HK3 →	+0.877	+0.067	<.001	<.001	3	5
GBM	MNDA →	+0.993	+0.069	<.001	<.001	3	5
OV	RPA1 →	-0.250	-0.043	.009	.008	3	5
BRCA	TNKS1BP1_S178 →	+0.611	+0.045	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050999 vs SMARCA4 — OV

Explore this scatter interactively →