Regulation of nitric-oxide synthase activity

Across TCGA patient cohorts, RNA activity of the Regulation of nitric-oxide synthase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL31P20, MAP2K1P1, and RPL17P51, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nitric-oxide synthase activity activity versus RPL31P20 in LUAD (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL31P20 →	+0.846	+0.210	<.001	.005	3	3
LUAD	MAP2K1P1 →	-0.081	-0.196	.001	.002	3	3
LUAD	RPL17P51 →	+0.207	+0.161	.007	.008	3	3
LUAD	ATP1B3P1 →	-0.127	-0.227	<.001	<.001	3	3
GBM	MUCL3 →	+0.117	+0.275	.008	.002	3	3
GBM	PWWP2B →	-0.309	-0.160	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050999 vs RPL31P20 — LUAD

Explore this scatter interactively →