Regulation of nitric-oxide synthase activity

Across TCGA cell cohorts, RNA activity of the Regulation of nitric-oxide synthase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESRP1, FGF21, and MCM9, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nitric-oxide synthase activity activity versus ESRP1 in LUNG_SCLC (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ESRP1 →	+1.189	+1.132	.005	.004	3	1
LUNG_SCLC	FGF21 →	+1.133	+1.625	<.001	<.001	3	1
LUNG_SCLC	MCM9 →	+0.840	+1.132	<.001	.004	3	1
LUNG_SCLC	GTF3A →	-1.597	-1.632	.004	<.001	3	1
LUNG_SCLC	WWP1 →	+0.799	+1.562	<.001	<.001	3	1
LUNG_SCLC	ABCC4 →	-3.005	-1.663	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050999 vs ESRP1 — LUNG_SCLC

Explore this scatter interactively →