Regulation of lipid catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of lipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COA3, IRS2, and EZH2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipid catabolic process activity versus COA3 in GBM (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COA3 →	-0.257	-0.138	<.001	.001	3	4
LUAD	IRS2 →	+0.947	+0.474	<.001	.001	2	5
LSCC	EZH2 →	-0.529	-0.241	.001	.001	3	4
LSCC	PLK4 →	-0.432	-0.199	.003	.007	3	4
UCEC	SYDE1 →	+0.462	+0.502	.009	.002	2	4
UCEC	LINC02813 →	+0.284	+0.363	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050994 vs COA3 — GBM

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