Regulation of lipid catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of lipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPO, ACVR1B, and LGALS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSPO grouped by Regulation of lipid catabolic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TSPO →	-3.631	-0.257	<.001	<.001	3	3
BLOOD_Myeloma	ACVR1B →	+1.617	+0.255	.005	.009	2	4
UPPER_AERODIGESTIVE_TRACT	LGALS1 →	-2.368	-0.233	<.001	.009	2	4
CNS	BABAM2 →	-0.776	-0.853	.004	.001	3	3
CNS	PTX3 →	-2.201	-0.695	.001	.001	3	3
CNS	FADD →	-0.810	-0.923	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSPO by Regulation of lipid catabolic process activity — BLOOD_Myeloma

Explore this box plot interactively →