Regulation of lipid catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of lipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM174A, CPT1A, and SCARB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipid catabolic process activity versus FAM174A in BONE (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FAM174A →	+1.899	+1.926	.002	.001	3	7
OESOPHAGUS	CPT1A →	+2.222	+1.714	<.001	<.001	3	6
PANCREAS	SCARB2 →	+1.103	+1.245	.002	<.001	3	6
CNS	CTSL →	+1.167	+0.929	.001	<.001	3	6
BLOOD_Lymphoma	GEMIN4 →	-0.945	-1.096	.002	.002	3	6
KIDNEY	UQCRQ →	+0.897	+1.703	.007	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050994 vs FAM174A — BONE

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