Detection of mechanical stimulus

Across TCGA cell cohorts, RNA activity of the Detection of mechanical stimulus pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM265, SCARB1, and GPR87, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of mechanical stimulus activity versus TMEM265 in PANCREAS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TMEM265 →	+2.863	+0.806	<.001	.008	3	5
UPPER_AERODIGESTIVE_TRACT	SCARB1 →	-1.695	-0.150	.001	.004	3	5
LUNG_NSCLC_LUAD	GPR87 →	+2.314	+0.814	.002	.003	3	5
LUNG_NSCLC_LUAD	ACSF2 →	+1.317	+0.694	<.001	.001	3	5
BREAST	MFSD4A →	+0.779	+0.229	.002	.002	3	5
URINARY_TRACT	CDH3 →	+5.827	+0.459	.002	.004	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050982 vs TMEM265 — PANCREAS

Explore this scatter interactively →