Detection of mechanical stimulus involved in sensory perception

Across TCGA cell cohorts, RNA activity of the Detection of mechanical stimulus involved in sensory perception pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR0B2, TK1, and KLF15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NR0B2 grouped by Detection of mechanical stimulus involved in sensory perception-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NR0B2 →	-0.144	-0.122	.004	<.001	3	4
LARGE_INTESTINE	TK1 →	-0.158	-0.056	.002	<.001	3	4
URINARY_TRACT	KLF15 →	-0.303	-0.073	<.001	<.001	3	3
OESOPHAGUS	TSNAX-DISC1 →	+0.119	+0.117	.008	.007	3	3
OESOPHAGUS	AK2 →	-0.118	-0.118	<.001	<.001	3	3
BLOOD_Myeloma	NOTCH4 →	-0.156	-0.093	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NR0B2 by Detection of mechanical stimulus involved in sensory perception activity — STOMACH

Explore this box plot interactively →