Detection of temperature stimulus involved in sensory perception of pain

Across TCGA patient cohorts, RNA activity of the Detection of temperature stimulus involved in sensory perception of pain pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANO1, NPDC1_S229, and BIN2_S259, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of temperature stimulus involved in sensory perception of pain activity versus ANO1 in HNSC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ANO1 →	+1.568	+0.122	<.001	<.001	3	6
BRCA	NPDC1_S229 →	+1.026	+0.078	.006	<.001	3	5
LSCC	BIN2_S259 →	-0.416	-0.069	.002	<.001	3	5
CCRCC	GSN →	+0.357	+0.059	.004	<.001	3	4
BRCA	IGFBP4 →	+0.638	+0.069	<.001	<.001	3	4
COAD	DDX27 →	-0.289	-0.042	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050965 vs ANO1 — HNSC

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