Detection of temperature stimulus involved in sensory perception of pain

Across TCGA pan-cancer cohorts, RNA activity of the Detection of temperature stimulus involved in sensory perception of pain pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 17 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Detection of temperature stimulus involved in sensory perception of pain pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and UCEC, show the opposite pattern, with higher activity associated with better survival.

KIRC, UCEC, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	III,IV	0.595	0.323	.001	81	view →
UCEC	DFS	Tertile	All	0.828	0.527	<.001	58	view →
SKCM	DFS	Median	All	0.762	0.540	<.001	47	view →
LGG	DFS	Median	All	0.518	0.319	<.001	42	view →
BRCA	OS	Tertile	III,IV	0.963	0.853	.001	35	view →
LUAD	DFS	Quartile	II,III,IV	0.552	0.779	.010	28	view →
DLBC	DFS	Median	IV	0.412	1.000	.006	25	view →
THYM	DFS	Quartile	II,III,IV	0.611	0.937	.002	21	view →
KIRP	DFS	Tertile	All	0.752	1.000	.002	21	view →
ACC	OS	Tertile	All	1.000	0.650	.011	12	view →
ESCA	DFS	Tertile	II,III,IV	0.481	0.206	.015	11	view →
SCLC	OS	Quartile	II,III,IV	0.543	0.855	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0050965–KIRC (DFS)

Open the KIRC breakdown →