Detection of temperature stimulus involved in sensory perception of pain

Across TCGA cell cohorts, RNA activity of the Detection of temperature stimulus involved in sensory perception of pain pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COMMD2, MYO19, and DCUN1D1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COMMD2 grouped by Detection of temperature stimulus involved in sensory perception of pain-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	COMMD2 →	+1.112	+0.266	.005	.001	3	4
LARGE_INTESTINE	MYO19 →	+0.743	+0.548	<.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	DCUN1D1 →	+0.793	+0.244	.002	.001	3	4
URINARY_TRACT	ZNF404 →	-1.037	-0.471	.003	.001	3	4
CNS	SLC29A1 →	+0.919	+0.584	.002	.004	3	4
CNS	AFTPH →	+0.310	+0.573	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COMMD2 by Detection of temperature stimulus involved in sensory perception of pain activity — UPPER_AERODIGESTIVE_TRACT

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