Detection of temperature stimulus involved in sensory perception of pain

Across TCGA cell cohorts, RNA activity of the Detection of temperature stimulus involved in sensory perception of pain pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POTEH, SLC15A4, and GSAP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POTEH grouped by Detection of temperature stimulus involved in sensory perception of pain-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	POTEH →	-0.210	-1.335	.004	.001	3	3
BREAST	SLC15A4 →	-0.190	-0.498	<.001	.008	3	3
BREAST	GSAP →	-0.143	-0.739	.006	.005	3	3
KIDNEY	PSMA7 →	+0.421	+0.165	<.001	.001	3	3
PANCREAS	GLS →	+0.173	+0.320	.003	.009	3	3
URINARY_TRACT	NLGN1 →	-0.270	-1.650	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POTEH by Detection of temperature stimulus involved in sensory perception of pain activity — STOMACH

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