Detection of light stimulus involved in sensory perception

Across TCGA patient cohorts, RNA activity of the Detection of light stimulus involved in sensory perception pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC1A, SMC3, and SNRPF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of light stimulus involved in sensory perception activity versus SMC1A in GBM (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC1A →	-0.257	-0.037	.004	.003	3	4
GBM	SMC3 →	-0.253	-0.043	.003	<.001	3	4
GBM	SNRPF →	-0.278	-0.054	.003	<.001	3	4
GBM	ATP6V0A1 →	+0.473	+0.052	.001	.001	3	4
HNSC	MACF1_S6032 →	+0.827	+0.067	<.001	.001	3	4
GBM	MYO5A_S600 →	+0.517	+0.052	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050962 vs SMC1A — GBM

Explore this scatter interactively →