Detection of light stimulus involved in sensory perception

Across TCGA patient cohorts, RNA activity of the Detection of light stimulus involved in sensory perception pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNS, PLA2G10, and SPP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of light stimulus involved in sensory perception activity versus GNS in GBM (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GNS →	-0.415	-0.551	.001	.003	3	4
UCEC	PLA2G10 →	-0.828	-0.859	<.001	<.001	3	3
LSCC	SPP1 →	-0.859	-0.350	.003	.001	3	3
LSCC	AKAP13 →	-0.315	-0.371	.006	.003	3	3
LSCC	MARCO →	-1.671	-0.361	<.001	.003	3	3
OV	REEP6 →	+0.836	+0.754	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050962 vs GNS — GBM

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