Detection of light stimulus involved in sensory perception

Across TCGA cell cohorts, RNA activity of the Detection of light stimulus involved in sensory perception pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DMKN, GABRR2, and MESD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DMKN grouped by Detection of light stimulus involved in sensory perception-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DMKN →	-1.620	-0.497	.009	.005	2	4
BLOOD_Leukemia	GABRR2 →	+0.466	+0.650	.003	.004	3	3
BLOOD_Leukemia	MESD →	+0.509	+0.715	.002	.007	3	3
BLOOD_Leukemia	PDIA6 →	+0.777	+0.659	<.001	.003	3	3
BLOOD_Leukemia	HYAL2 →	+0.635	+0.884	.005	.003	3	3
LUNG_SCLC	IGF2BP2 →	+3.365	+1.299	.009	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DMKN by Detection of light stimulus involved in sensory perception activity — SKIN

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